Selected Publications:
accessible link on https://scholar.google.com/citations?user=a2nss_kAAAAJ&hl=en
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2023 Katoch O, Ungalara R, Kaminski T, Li A, Dubey RK, Burholt I, Gudapati S, Pradhan-Sundd T. Long-term l-glutamine treatment reduces hemolysis without ameliorating hepatic vasoocclusion and liver fibrosis in a mouse model of sickle cell disease. Biomedicines. 2023 August 28. Accepted. Invited article for special issue on Sickle Cell Disease. 2022 Pradhan-Sundd T, Kato GJ, Novelli EM. Molecular Mechanisms of Hepatic Dysfunction in Sickle Cell Disease: Lessons From The Townes Mouse Model. Am J Physiol Cell Physiol. 2022 Jun 27. doi: 10.1152/ajpcell.00175.2022. Online ahead of print. PMID: 35759437 Review. Vats R, Kaminski TW, Brzoska T, Leech JA, Tutuncuoglu E, Katoch O, Jonassaint JC, Tejero J, Novelli EM, Pradhan-Sundd T, Gladwin MT, Sundd P.Liver to lung microembolic NETs promote Gasdermin-D-dependent inflammatory lung injury in Sickle Cell Disease.Blood. 2022 Jun 23:blood.2021014552. doi: 10.1182/blood.2021014552. Online ahead of print. PMID: 35737916. Kaminski TW, Ju E-M, Gudapati S, Vats R, Arshad S, Dubey RK, Katoch O, Tutuncuoglu E, Frank J, Brzoska T. Stolz DB, Watkins SC, Chan SY, Ragni MV, Novelli EM, Sundd P, Pradhan-Sundd T. Defenestrated endothelium delays liver directed gene transfer in Hemophilia A mice. Manuscript Accepted, In Press, Blood Advances, April 2022. Vats R, Li Z, Ju EM, Dubey RK, Kaminski TW, Watkins S, Pradhan-Sundd T. Intravital imaging reveals inflammation as a dominant pathophysiology of age-related hepatovascular changes. Am J Physiol Cell Physiol. 2022 Jan 5. doi:10.1152/ajpcell.00408.2021. Online ahead of print. PMID: 34986022. 2021 Vats R, Kaminski T W, Pradhan-Sundd T. Intravital imaging of hepatic blood biliary barrier in live mice. Manuscript accepted, in press. August, 2021. Current protocols in Cytometry. 2021. Vats R, Kaminski T, Ju E-M, Brozska T, Tutuncuoglu E, Tejero J, Novelli E, Sundd P, Pradhan-Sundd T. P-selectin deficiency promotes liver senescence in sickle cell disease mice. Blood. 2021 Feb 22:blood.2020009779. PMID: 33619560. Pradhan-Sundd T*, Gudapati S, Kaminski T, Ragni M. Exploring the complex role of procoagulant Factor VIII in chronic liver disease. Cellular molecular gastroenterology hepatology . Review Article. Cell Mol Gastroenterol Hepatol. 2021 Mar 8:S2352-345X(21)00052-7.PMID: 33705963.*first and corresponding author. Pradhan-Sundd T*, Liu S, Singh S, Podder M, Ko S, Bell A, Franks J, Huck I, Stolz D, Apte U, Ranganathan S, Nejak-Bowen K, Monga SP*. Dual β-catenin and γ-catenin loss in hepatocytes impacts their polarity through altered transforming growth factor beta and hepatocyte nuclear factor 4 alpha signaling. Am J Pathol. 2021 Mar 1.PMID: 33662348.*first and co-corresponding author. Pradhan-Sundd T. Making the best of a competition: the Creb3L3-SREBP axis in arteriosclerosis. Editorial. Cell Mol Gastroenterol Hepatol. 2021 Feb 6:S2352-345X(21)00002-3. PMID: 33556363. 2020 Crompton D, Vats R , Pradhan-Sundd T , Sundd P , Kameneva MV .Drag-reducing polymers improve hepatic vaso-occlusion in SCD mice. Blood Adv. 2020 Sep 22;4(18):4333-4336. PMID: 32915976. PMCID: PMC7509886. Vats R, Luo S, …...Gladwin M, Kato G, Ramakrishnan S, Sundd P, Monga SP*, Pradhan-Sundd, T*. Impaired bile secretion promotes hepatobiliary injury in sickle cell disease. Hepatology, 2020 Mar 19. PMID: 32190913. Vats R, Tejero J, Gray S, Tutuncouglu E, Pradhan-Sundd T, Sundd P. Tandem P-selectin glycoprotein ligand immunoglobulin (TSGL-Ig) prevents lung vaso-occlusion in Sickle Cell Disease mice.Exp Hematol. 2020 Apr;84:1-6.e1. PMID: 32243995 Pradhan-Sundd T. Sirtuin-6 in Hepatic Fibrosis: Does Cell Type Matter? Cell Mol Gastroenterol Hepatol. 2020;10(2):420-421. PMID: 32473838 (editorial). Bennewitz, M, Tutuncuoglu, E, Gudapati, S, Brzoska, T, Pradhan-Sundd, T, Sundd, P. P-selectin deficient mice to study pathophysiology of Sickle Cell Disease. Blood Adv. 2020 Jan 28;4(2):266-273. PMID: 31968076 2019 Pradhan-Sundd T, Kosar K, Saggi H, Zhang R, Vats R, Cornuet P, Green S, Singh S, Zeng G, Sundd P, Nejak-Bowen K. Wnt/β-Catenin signaling plays a protective role in the Mdr2 KO murine model of cholestatic liver disease. Hepatology. 2019 Sep 6. PMID: 31489648. Nolfi-Donegan D, Pradhan-Sundd, T, Prichward K, Hillery C. Redox signaling in sickle cell disease. Current opinions in Physiology. May, 2018. PMID: 31240269. (Review article). Vats, R, Brzoska,T, Bennewitz,M, Jimenez,M, Pradhan-Sundd T, Tutuncuoglu E, Jonassaint, J, Gutierrez, E, Watkins S, Shiva, S, Scott, M, Morelli A, Neal M, Kato G, Gladwin M, Sundd P. Platelet extracellular vesicles drive inflammasome-IL1β-dependent lung injury in Sickle Cell Disease. American Journal of Respiratory and Critical Care Medicine. PMID: 31498653. Adebayo Michael AO, Ko S, Tao J, Moghe A, Yang H, Xu M, Russell JO, Pradhan-Sundd T, Liu S, Singh S, Poddar M, Monga JS, Liu P, Oertel M, Ranganathan S, Singhi A, Rebouissou S, Zucman-Rossi J, Ribback S, Calvisi D, Qvartskhava N, Görg B, Häussinger D, Chen X, Monga SP. Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations. Cell Metab. 2019 May 7; 29(5). PMID: 30713111. Pradhan-Sundd T, Monga SP. Blood-Bile Barrier: Morphology, Regulation, and Pathophysiology. Gene Expr. 2019 Apr 18; 19(2):69-87. (also featured on the cover) (Review Article). 2018 Jiang A, Okabe H, Popovic B, Preziosi ME, Pradhan-Sundd T, Poddar M, Singh S, Bell A, England SG, Nagarajan S, Monga SP. Loss of Wnt Secretion by Macrophages Promotes Hepatobiliary Injury after Administration of 3,5-Diethoxycarbonyl-1, 4-Dihydrocollidine Diet. Am J Pathol. 2019 Mar; 189(3):590-603.PMID: 30610845. Pradhan-Sundd, T. Vats, R. Russell, J, Vats R, Russell JO, Singh S, Michael AA, Molina L, Kakar S, Cornuet P, Poddar M, Watkins SC, Nejak-Bowen KN, Monga SP, Sundd P. Dysregulated tight junctional proteins and bile transporters enables chronic liver injury. Gastroenterology. 2018 Oct; 155(4):1218-1232.e24. PMID:29964040. Pradhan-Sundd, T. Zhou L, Vats, R. Molina L, Singh S, Watkins S, Sundd, P and Monga SP., Dual beta-catenin and gamma-catenin loss disrupts hepatic tissue barrier to cause cholestatic liver disease. Hepatology. 2018 Jun; 67(6):2320-2337. PMID:29023813. (With commentary). Molina L, Bell D, Tao J, Preziosi M, Pradhan-Sundd T, Singh S, Poddar M, Ranganathan S, Chikina M, Monga SP. Hepatocyte-derived lipocalin-2 is a potential serum biomarker reflecting tumor burden in hepatoblastomas. Am J Pathol. 2018 Aug; 188(8):1895-1909. doi: 10.1016/j.ajpath.2018.05.006. 2017 Kikuchi A, Pradhan-Sundd, T. Singh S, Nagarajan S, Loizos N, Monga SP. Platelet-Derived Growth Factor Receptor α Contributes to Human Hepatic Stellate Cell Proliferation and Migration. Am J Pathol. 2017 Jul 20. pii: S0002-9440(17)30329-2. Puliga E, Min Q, Tao J, Zhang R, Pradhan-Sundd T, Poddar M, Singh S, Columbano A, Yu J, Monga SP. Thyroid hormone receptor-beta agonist GC-1 inhibits Met-β-catenin driven hepatocellular cancer. Am J Pathol. 2017 Aug 11. pii: S0002-9440(17)30403-0. Pradhan-Sundd T*, Hall ET*, Samnani F, Verheyen EM. The protein phosphatase 4 complex promotes the Notch pathway and wingless transcription. Biol Open. 2017 Aug 15; 6(8):1165-1173. (* co-first authors) 2016 Zhou L, Pradhan-Sundd, T. Poddar M, Singh S, Kikuchi A, Stolz DB, Shou W, Li Z, Nejak-Bowen KN, Monga SP. Mice with Hepatic Loss of the Desmosomal Protein γ-Catenin Are Prone to Cholestatic Injury and Chemical Carcinogenesis. Am J Pathol. 2015 Dec; 185(12):3274-89. PMID: 26485505. Ma L, Umasankar PK, Wrobel AG, Lymar A, McCoy AJ, Holkar SS, Jha A, Pradhan-Sundd, T. Watkins SC, Owen DJ, Traub LM. Transient Fcho1/2⋅Eps15/R⋅AP-2 Nanoclusters Prime the AP-2 Clathrin Adaptor for Cargo Binding. Dev Cell. 2016 Jun 6; 37(5):428-43. 2015 Pradhan-Sundd, T. and Verheyen, E M. The Myopic-Hrs nexus regulates endosomal trafficking of Frizzled. MBoC. 2015 Sep 15; 26(18):3329-42. Fernandes VM, Pradhan-Sundd, T, Blaquiere JM and Verheyen EM . Ras/Mek/Mapk regulation of heparin sulfate proteoglycans determines morphogenetic furrow initiation in the Drosophila eye. Developmental Biology, S0012-1606(15)00147-5. (Also featured on the cover). Swarup, S. Pradhan-Sundd, T. and Verheyen, E M. Genome wide identification of phosphoregulators of Wnt signalling in Drosophila. Development, 142(8):1502-15. 2014 Pradhan-Sundd, T. and Verheyen, E M. The role of Bro1 domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless. Developmental Biology.392:93-107. (Also featured on the cover). |