Scanning electron micrograph of hepatic sinusoid showing liver sinusoidal endothelial fenestration (pores, green) in hemophilia mice.
Welcome to the Pradhan-Sundd Lab
Our goal is to gain a better understanding of the involvement of hepato-vascular cells (liver sinusoidal endothelial cells, tissue resident macrophages and monocytes) in hematological liver diseases. Our disease models include humanized mouse model of sickle cell disease induced acute and chronic liver injury, iron overload in liver, murine models of hemolysis, vasculopathy, stressed erythrophagocytosis and hemophilia mouse model .
We are currently funded by NIH- NIDDK, American Society of Hematology (ASH) and VMI pilot grant award funds for our research. We use murine models, tissue culture, human samples and molecular, biochemical, advanced imaging (Intravital Microscopy) and bioinformatics tools for our research.
We are currently funded by NIH- NIDDK, American Society of Hematology (ASH) and VMI pilot grant award funds for our research. We use murine models, tissue culture, human samples and molecular, biochemical, advanced imaging (Intravital Microscopy) and bioinformatics tools for our research.